What is the most appropriate test in detecting prostate cancer in patients with intermediate prostate specific antigen levels?
Authors
Abstract:
Abstract Background: Regarding the variety of tests present for detecting and also screening prostate cancer and also bearing in mind the advantages and disadvantages of these tests we decided to re-evaluate these tests (total prostate specific antigen and all of its modifications) in detecting prostate cancer in men with intermediate serum PSAlevels. Methods: Following a cross sectional study, 100 consecutive men with intermediate serum PSA levels and normal digital rectal examination (DRE) were incorporated. Total and free PSA levels and TRUS-guided systematic prostate biopsy were performed. PSA density, percent free PSA and percent free PSA density were calculated and compared. Statistical analysis was carried out using STATA8 SE. Results: Overall, 27 patients had prostate cancer and 73 had benign prostate pathology. PSA density had the greatest area under the curve (AUC) which was significantly higher than percent free PSA density (0.685 vs. 0.448, p<0.001). The AUC of percent free PSA density was not different between benign and malignant biopsy results nor was significantly higher than the AUC of percent free PSA (0.308) or any other screening tests. Conclusion: PSAdensity was the most accurate screening test for prostate cancer in patients with PSA levels of 4-10 ng/ml and normal DRE. The percent free PSA density was not significantly more accurate than percent free PSA and regarding the costs of transrectal ultrasonography, it can be concluded that the percent free PSA is more cost-effective and hence more appropriate than percent free PSA density to screen prostate cancer.
similar resources
what is the most appropriate test in detecting prostate cancer in patients with intermediate prostate specific antigen levels?
abstract background: regarding the variety of tests present for detecting and also screening prostate cancer and also bearing in mind the advantages and disadvantages of these tests we decided to re-evaluate these tests (total prostate specific antigen and all of its modifications) in detecting prostate cancer in men with intermediate serum psalevels. methods: following a cross sectional st...
full textAge Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men
Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of he...
full textDefining prostate specific antigen progression after radical prostatectomy: what is the most appropriate cut point?
PURPOSE The most appropriate definition of biochemical progression after radical prostatectomy and radiation therapy is uncertain. We analyzed the effect of using various prostate specific antigen (PSA) end point definitions for defining biochemical progression after radical prostatectomy and attempted to determine the best PSA cut point to use. Aspects of the American Society for Therapeutic R...
full textProstate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen , Bandar Abbas, Iran
Introduction: Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods: In this corss-sectional study, prostatic adenocarcin...
full textmolecular detection of prostate specific antigen in patients with prostate cancer or benign prostate hyperplasia the first investigation from iran
prostate cancer is the second common form of cancer in men. detection of circulating prostate specific antigen (psa) transcripts has effectively been used for early diagnosis of prostate cancer cells. this investigation employed a reverse transcriptase polymerase chain reaction (rt-pcr) technique to distinguish the patients with either localized or metastatic prostate cancer (cap) vs. benign pr...
full textage specific reference levels of serum prostate-specific antigen, prostate volume and prostate specific antigen density in healthy iranian men
background: it is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum psa in iranian population. objective: to determine age-specific reference ranges for serum prostate-specific antigen (psa) concentration and psa density (psad) and prostate volumes in a population of he...
full textMy Resources
Journal title
volume 22 issue 4
pages 191- 197
publication date 2009-02
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023